Disable popup blocker before clicking

page1 page2 page3 page4 page 5 page 6 page 7

Summary Permanent Seed Brachytherapy

PSA results equivalent to surgery, better than external beam
Urinary continency rate higher than surgery or external beam
Sexual potency rate higher than surgery or external beam
Shorter recovery time than surgery
Outpatient procedure
Less patient discomfort
Cost competitive
Surgery candidates are all seed candidates

Modern Prostate Brachytherapy
CA Cancer Journal for Clinicians
2000;50:380-393 Ragde H. et al

“The brachytherapy study reported here, based on thousands of PSA determinations and a high post implant biopsy rate, documents that interstitial radiation is an effective treatment for early stage prostate cancer. Brachytherapy achieves long term disease free survival rates that are comparable to the best results reported from radical prostatectomy series and substantially better results than reported from conventional external beam therapy.”

What is the Role of Interstitial Brachytherapy?
Doggett, SW in: Bowsher, W., Peeling, W., editors. Challenges in Prostate Cancer . 1st ed. Blackwell Science, London, 2000

“ Long term results for ultrasound guided transperineal radioisotope prostate cancer seeding exist and based on PSA measurements appear to be equivalent to the results of comparable radical prostatectomy series and superior to the results of external beam radiotherapy series .”

Comparison Summary

PSA control rate for seeds and surgery is the same.
PSA control rate for external beam radiation of any type is not as good as for seeds or surgery.
Urinary incontinency and sexual impotency rates are better for seeds than for surgery or external beam radiation of any type.
Recovery time for seeds is much faster than for surgery

History of Prostate Brachytherapy
modified from HH Holm US in Med & Biol. 1998;20:779-91.,Sem Surg Onc 1997;13:431-37

Brachytherapy first suggested 1901 Pierre Curie
Intra urethral radium 1914 Pasteau and Degrais
Trans perineal radium needle implant 1917 Barringer
Ultrasound transducer with needle canal 1969 Kratochwil
Retropubic freehand seed placement 1972 Hilaris
Dynamic US scanning puncture 1974 Pederson & Holm
Transverse Ultrasound guided needles/prostate 1981 Holm
Sagittal Ultrasound guided needles/prostate 1981 Saitoh
Herlev technique ultrasound guided seeding 1983 Holm
USA introduction /advances 1984 Ragde Blasko Grimm
Intraoperative image registered treatment planning 1999 Burdette/CMS Image Guidance /Doggett
Prostascint image guided brachytherapy 2004 Doggett
Nerve-Sparing Bracytherapy 2004 Doggett

Original technique of freehand seed insertion through an open abdominal incision was abandoned because seeds could not be placed uniformly

Invention of transrectal ultrasound allowed evaluation of the prostate and paved the way for transperineal template guided brachytherapy

“New equipment for transrectal ultrasonomography has been developed... Transrectal ultrasonotomography is a promising new diagnostic technique that yields abundant information not available with former methods of examination. The procedure is likely to become one of the most important diagnostic tools in the field of urology.”
Transrectal ultrasonotomography of the prostate
Watanabe H, Igari D, Tanahashi Y, Harada K, Saitoh M. J Urol. 1975 Nov;114(5):734-9.

Disable popup blocker before clicking

page1 page2 page3 page4 page 5 page 6 page 7